Basic Information
VIS ID
TVIS10006418
Fusion event
HBV-LOC400867 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1827
Integrated sequence
TCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATT| |TGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAG
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh38
Start
38923345 (Hg38)
End
38923345 (Hg38)
Location type
Intron
Target gene
LOC400867
Nearest miRNA
hsa-let-7c/Upstream/3202537; hsa-mir-3197/Downstream/523665;
Nearest TSS
ENST00000624081/Upstream/3824; ENST00000608767/Downstream/2835;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/100420, chr21-CpG: 115/Downstream/259493
Upstream sequence
TGTTTCTGAATTACATGTC
Junction sequence
TGTTTCTGAATTACATGTCAAAAAGTTGCATGGTGCTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate