Basic Information
VIS ID
TVIS10006443
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1812
Integrated sequence
CGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATG| |GAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGC
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh38
Start
35811667 (Hg38)
End
35811667 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA18A
Nearest miRNA
hsa-mir-1-2/Upstream/219861; hsa-mir-122/Downstream/93151;
Nearest TSS
ENST00000575820/Upstream/95297; ENST00000587719/Downstream/154173;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/229367, chr18-CpG: 53/Downstream/138298
Nearby gene
GALNT1(-99833) ; MIR187(+93150) ;
Nearest cancer related gene
MIR187(TSG, +93150) ;
Upstream sequence
TTTATGTCCAACAGAC
Junction sequence
TTTATGTCCAACAGACGCTGGTGAACAGACCAATTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate