PPP2R2C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006449
Fusion event
HBV-PPP2R2C integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2848
Integrated sequence
CAAGAAGATGAGGCATAGCAGCAGGATGAAGAGGAAGATGATAAAACGCCGCAGACACATCCAGCGATAACCAGGACAAGTTGGAGGACAAGAGGTTGGT| |GAGTGATTGGAGGTTGGGGACTGCGAATTTTGGCCAAGACACACGGTAGTTCCCCCTAGAAAATTGAGAGAAGTCCACCACGAGTCTAGACTCTGCGGTA
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh38
Start
6436575 (Hg38)
End
6436575 (Hg38)
Location type
Intron
Fragile sites / regions
FRA4A
Target gene
PPP2R2C
miRNAs that regulate target gene
hsa-mir-142-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/513247; hsa-mir-12113/Downstream/873875;
Nearest TSS
ENST00000502981/Upstream/15457; ENST00000504960/Downstream/35111;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/57757, chr4-CpG: 222/Downstream/33873
Nearest cancer related gene
PPP2R2C(TSG, No orient, 0)
Upstream sequence
TGTTACTAGAGTTCCCT
Junction sequence
TGTTACTAGAGTTCCCTAGTAACAAGGCATGGGGACGAATCTTTCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate