Basic Information
VIS ID
TVIS10006450
Fusion event
HBV-chr2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1804
Integrated sequence
GTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAG| |CAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGG
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
GRCh38
Start
240851310 (Hg38)
End
240851310 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA2J
Nearest miRNA
hsa-mir-10b/Upstream/395221; hsa-mir-3133/Downstream/626595;
Nearest TSS
ENST00000437798/Upstream/31002; ENST00000472436/Downstream/17169;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/18533, chr2-CpG: 24/Downstream/37050
Nearby gene
KIF1A(-31002) ; AGXT(+17434) ;
Upstream sequence
GGTCCTCCTGCCCCACAT
Junction sequence
GGTCCTCCTGCCCCACATGCAGACCAATTTATGCCTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate