Basic Information
VIS ID
TVIS10006451
Fusion event
HBV-LINC02054 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1813
Integrated sequence
GACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGG| |AAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCA
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh38
Start
184416743 (Hg38)
End
184416743 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
LINC02054
Nearest miRNA
hsa-let-7g/Upstream/175254; hsa-mir-1248/Downstream/836467;
Nearest TSS
ENST00000440867/Upstream/15113; ENST00000645656/Downstream/3126;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/30012, chr3-CpG: 23/Downstream/74563
Nearby gene
CHRD(-26908) ; EPHB3(+145055) ;
Upstream sequence
CAGGTGCGCCATAACT
Junction sequence
CAGGTGCGCCATAACTTGCTGGTGCGCAGACCAATT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate