Basic Information
VIS ID
TVIS10006455
Fusion event
HBV-LINC02172 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1829
Integrated sequence
GTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTG| |CGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAG
Host Sequence
Chromosome
chr4
Cytoband
q28.3
Reference genome
GRCh38
Start
137562796 (Hg38)
End
137562796 (Hg38)
Location type
Intronic
Target gene
LINC02172
Nearest miRNA
hsa-mir-12113/Upstream/12055489; hsa-mir-1305/Downstream/5780664;
Nearest TSS
ENST00000502981/Upstream/17065; ENST00000506420/Downstream/92378;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/750208, chr4-CpG: 21/Downstream/997784
Nearby gene
PCDH18(-30298) ; LINC00616(+464626) ;
Downstream sequence
AATTCTCAATCATTTTCCTTT
Junction sequence
AGCACCATGCAACTTTTTCAAATTCTCAATCATTTTCCTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate