Basic Information
VIS ID
TVIS10006457
Fusion event
HBV-LINC01257 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1811
Integrated sequence
GCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCAT| |GGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCG
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh38
Start
131196616 (Hg38)
End
131196616 (Hg38)
Location type
Intron
Fragile sites / regions
FRA12E
Target gene
LINC01257
Nearest miRNA
hsa-let-7i/Upstream/2902438; hsa-mir-6763/Downstream/1385381;
Nearest TSS
ENST00000382841/Upstream/31605; ENST00000536191/Downstream/10591;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/31553, chr12-CpG: 108/Downstream/101932
Upstream sequence
ACAACGTTCACTTTTGTT
Junction sequence
ACAACGTTCACTTTTGTTCTGGTGCGCAGACCAATTTA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate