Basic Information
VIS ID
TVIS10006459
Fusion event
HBV-RAD21-AS1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1825
Integrated sequence
GGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATA| |TTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGC
Host Sequence
Chromosome
chr8
Cytoband
q24.11
Reference genome
GRCh38
Start
116876744 (Hg38)
End
116876744 (Hg38)
Location type
Exon
Target gene
RAD21-AS1
Nearest miRNA
hsa-mir-12123/Upstream/1944; hsa-mir-10400/Downstream/2448427;
Nearest TSS
ENST00000518652/Upstream/1878; ENST00000523536/Downstream/61455;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1664, chr8-CpG: 45/Downstream/61489
Downstream sequence
CAGCCATAAAAAAGAAAAA
Junction sequence
CACCAGCACCATGCAACTTTGCAGCCATAAAAAAGAAAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate