Basic Information
VIS ID
TVIS10006461
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
2141
Integrated sequence
AAGGTTCAGGTATTGTTTACACAGAAAGGCCTTGTAAGTTGGCGAGAAAGTGAAAGCCTGCTTAGATTGAATACATGCATACAAAGGCATCAACGCAGGA| |TAACCACATTGTGTAAAAGGGGCAGCAAAACCCAAAAGACCCACAATTCGTTGACATACTTTCCAATCAATAGGCCTGTTAATAGGAAGTTTTCTAAAAC
Host Sequence
Chromosome
chr1
Cytoband
p21.2
Reference genome
GRCh38
Start
101626622 (Hg38)
End
101626622 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA1E
Nearest miRNA
hsa-mir-101-1/Upstream/1345314; hsa-mir-11399/Downstream/6270601;
Nearest TSS
ENST00000473358/Upstream/276573; ENST00000415532/Downstream/12926;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/389433, chr1-CpG: 85/Downstream/1898848
Nearby gene
LINC01307(-249310) ; OLFM3(+175943) ;
Upstream sequence
TGCTTCCTGCATCCCAGCC
Junction sequence
TGCTTCCTGCATCCCAGCCnnnnnnnnnnGCTGGATCTTCCAAATTTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate