Basic Information
VIS ID
TVIS10006463
Fusion event
HBV-chr13 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1826
Integrated sequence
GTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATAT| |TTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCA
Host Sequence
Chromosome
chr13
Cytoband
q31.2
Reference genome
GRCh38
Start
88267974 (Hg38)
End
88267974 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/649234; hsa-mir-1267/Downstream/1963208;
Nearest TSS
ENST00000623511/Upstream/125107; ENST00000424165/Downstream/272890;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/590344, chr13-CpG: 41/Downstream/1095184
Nearby gene
LINC00397(-457454) ; LINC00433(+272854) ;
Downstream sequence
AAAGAGCTTCAGCACAGCA
Junction sequence
ACCAGCACCNTGCAACTTTTAAAGAGCTTCAGCACAGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate