Basic Information
VIS ID
TVIS10006490
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1829
Integrated sequence
GTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTG| |CGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAG
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh38
Start
2162764 (Hg38)
End
2162764 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/28555; hsa-let-7a-2/Downstream/10299;
Nearest TSS
ENST00000527297/Upstream/1423; ENST00000437313/Downstream/4010;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/6951, chr11-CpG: 77/Downstream/3494
Nearby gene
INS(-1555) ; TH(+1164) ;
Upstream sequence
CTGAGCCATGCCACAGC
Junction sequence
CTGAGCCATGCCACAGCCATGAAAAAGTTGCATGGTGCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate