Basic Information
VIS ID
TVIS10006492
Fusion event
HBV-TEX41 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1816
Integrated sequence
CCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAA| |CGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTA
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh38
Start
145043331 (Hg38)
End
145043331 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2S ; FRA2K
Target gene
TEX41
Nearest miRNA
hsa-mir-128-1/Upstream/4456646; hsa-mir-10b/Downstream/4286947;
Nearest TSS
ENST00000437798/Upstream/19899; ENST00000626394/Downstream/14360;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/518843, chr2-CpG: 49/Downstream/1543902
Downstream sequence
GAAGTATTCCAAGATAACTTCT
Junction sequence
TGGNGNGTTCACCAGCACCAGAAGTATTCCAAGATAACTTCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate