VISDB Viral Integration Site DataBase

VIS ID

TVIS10006494

Fusion event

HBV-RPH3A integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1715

Integrated sequence

CAGATGAGAAGGCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGA| |CCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAA

Chromosome

chr12

Cytoband

q24.13

Reference genome

Start

End

112612606 (Hg38)

Location type

Intronic

Fragile sites / regions

FRA12E ; FRA12D

Target gene

miRNAs that regulate target gene

hsa-mir-106a-5p ; hsa-mir-7106-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-765 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-5197-3p ; hsa-mir-574-5p ; hsa-mir-493-5p ; hsa-mir-4666a-5p ; hsa-mir-6867-5p ; hsa-mir-3177-5p ; hsa-mir-124-5p ; hsa-mir-3650 ; hsa-mir-4455

Nearest miRNA

hsa-let-7i/Upstream/449285; hsa-mir-1178/Downstream/82428;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/36881, chr12-CpG: 37/Downstream/325774

Nearby gene

PTPN11(-102693) ; MIR1302-1(+82427) ;

Downstream sequence

CCAGGCTGGAGTGCAATGA

Junction sequence