VISDB Viral Integration Site DataBase

VIS ID

TVIS10006496

Fusion event

HBV-TGFBRAP1 integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1763

Integrated sequence

CGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACA| |AAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAA

Chromosome

chr2

Cytoband

q12.1

Reference genome

Start

End

105251384 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-122-5p ; hsa-mir-628-3p ; hsa-mir-92a-3p ; hsa-mir-181a-5p ; hsa-mir-218-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-5696 ; hsa-mir-4729 ; hsa-mir-4428 ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-6501-3p ; hsa-mir-892c-5p ; hsa-mir-2681-3p ; hsa-mir-181c-5p

Nearest miRNA

hsa-mir-1285-2/Upstream/2819018; hsa-mir-10b/Downstream/3890106;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/8757, chr2-CpG: 17/Downstream/18054

Nearby gene

GPR45(-7917) ; TGFBRAP1(+13005) ;

Downstream sequence

TTGTCTGAGATGTGGGGA

Junction sequence