Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006500
Fusion event
HBV-APBA1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
Start
End
69450228 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-450a-1-3p ; hsa-mir-7977 ; hsa-mir-8059 ; hsa-mir-4471 ; hsa-mir-1292-5p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-2114-5p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-3199 ; hsa-mir-365a-5p ; hsa-mir-365b-5p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-8052 ; hsa-mir-892a
Nearest miRNA
hsa-mir-101-2/Upstream/28216393; hsa-let-7a-1/Downstream/1359747;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/37716, chr9-CpG: 16/Downstream/65743
Upstream sequence
GTGGGTGGTGTGTTATGGTTTCTAGAAATAGCTTTTCAAATTCCATGCGCAGGTTCCCCCTCCCACAGTGCTTCCCCAATTCGCTCCGACATTTAATTTT
Downstream sequence
CTTGAGTTAAAAATAAATAAACACACAGAAACACTTCTCTGCAAGGAAAAAGTTGAGAAAAAAGAAAAAGTGATGCTGAAGTTATCACAACCAAAAGGCT
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.