Basic Information
VIS ID
TVIS10006502
Fusion event
HBV-LHCGR integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1814
Integrated sequence
ACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGA| |AACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAG
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh38
Start
48690599 (Hg38)
End
48690599 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
LHCGR
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-513a-3p
Nearest miRNA
hsa-mir-1301/Upstream/1312829; hsa-mir-10b/Downstream/369004;
Nearest TSS
ENST00000437798/Upstream/20802; ENST00000463040/Downstream/32915;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/72753, chr2-CpG: 28/Downstream/64883
Upstream sequence
CGTAGTTCTCTGAATAAGTTCT
Junction sequence
CGTAGTTCTCTGAATAAGTTCTGTGCTGGNGAMCMCNCCAAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate