Basic Information
VIS ID
TVIS10006504
Fusion event
HBV-GUSBP2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1800
Integrated sequence
GAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGC| |CTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGC
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh38
Start
26933909 (Hg38)
End
26933909 (Hg38)
Location type
Intron
Fragile sites / regions
FRA6C
Target gene
GUSBP2
Nearest miRNA
hsa-mir-3691/Upstream/8362029; hsa-mir-10398/Downstream/213717;
Nearest TSS
ENST00000381078/Upstream/247668; ENST00000607607/Downstream/23083;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/37912, chr6-CpG: 43/Downstream/85910
Upstream sequence
TTTCTACAGGTCTGAAGGTG
Junction sequence
TTTCTACAGGTCTGAAGGTGAACACACCAATTTATGCCTACAGCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate