Basic Information
VIS ID
TVIS10006513
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1810
Integrated sequence
AGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCA| |TGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCC
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh38
Start
107067262 (Hg38)
End
107067262 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/2582797; hsa-mir-10400/Downstream/5576231;
Nearest TSS
ENST00000518652/Upstream/297017; ENST00000520037/Downstream/228279;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/408899, chr8-CpG: 92/Downstream/1015365
Nearby gene
ABRA(-297018) ; ANGPT1(+182219) ;
Upstream sequence
CAGGCAACAGGCAATA
Junction sequence
CAGGCAACAGGCAATATGGTGAACACACCAATTTAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate