ABCC2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006515
Fusion event
HBV-ABCC2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1791
Integrated sequence
AGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGG| |CAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAA
Host Sequence
Chromosome
chr10
Cytoband
q24.2
Reference genome
GRCh38
Start
99810494 (Hg38)
End
99810494 (Hg38)
Location type
Intron
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ABCC2
miRNAs that regulate target gene
hsa-mir-490-3p
Nearest miRNA
hsa-mir-107/Upstream/885926; hsa-mir-1307/Downstream/1164491;
Nearest TSS
ENST00000439456/Upstream/18205; ENST00000427093/Downstream/79001;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/77897, chr10-CpG: 41/Downstream/29636
Downstream sequence
AGTGTGTGGGATTGGGAA
Junction sequence
GTACTAGGAGGCTGTAGGCAAGTGTGTGGGATTGGGAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate