Basic Information
VIS ID
TVIS10006523
Fusion event
HBV-NOL4L integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh38
Start
32473272 (Hg38)
End
32473272 (Hg38)
Location type
Intron
Target gene
NOL4L
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/235425; hsa-mir-1-1/Downstream/1575847;
Nearest TSS
ENST00000382410/Upstream/23517; ENST00000620523/Downstream/1463;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/16934, chr20-CpG: 226/Downstream/9114
Upstream sequence
CACTGCTCTGGGTTTCTGAACAACTGTCCCAGACCCTTCTTGTGGGGGACCACAGCCTGTGGCCCCAGCTGGGCTCTGCAGGCACCGCCCTCAGTGTTCC
Downstream sequence
TTGGGCGTGGCCTCAATCGGCTCAGTTGAGGCGGGAGGTCAGCTGCTGCGCTTGTCCCAGCCCCAGAGCCCCCCAGAGCACGTGGCTGCCCCCGCCGGTC
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
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