Basic Information
VIS ID
TVIS10006532
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr4
Cytoband
q32.2
Reference genome
GRCh38
Start
163110338 (Hg38)
End
163110338 (Hg38)
Location type
Intronic
Target gene
LOC101928081 ; NAF1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-mir-12113/Upstream/16710; hsa-mir-1305/Downstream/2275904;
Nearest TSS
ENST00000502981/Upstream/1553; ENST00000504628/Downstream/7113;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/4006355, chr4-CpG: 71/Downstream/55971
Nearby gene
MIR4454(-16710) ; NAF1(+16369) ;
Upstream sequence
tcatctgtgctgtcacttttcgtggtttcagttaccttcagtcaaccatggtctgaaaataggtgaggtaaaatcagatattttgagagagaaagaatac
Downstream sequence
attcacataactgttactacaaaatattgttataattgtcctattgtattattagttgttgttaatctcttactgtgcctatttcctaaattaatcttta
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate