Basic Information
VIS ID
TVIS10006533
Fusion event
HBV-PMF1-BGLAP integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1827
Integrated sequence
TCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATT| |TGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAG
Host Sequence
Chromosome
chr1
Cytoband
q22
Reference genome
GRCh38
Start
156213591 (Hg38)
End
156213591 (Hg38)
Location type
Intron
Target gene
PMF1-BGLAP
Nearest miRNA
hsa-mir-101-1/Upstream/262255; hsa-mir-1182/Downstream/206750;
Nearest TSS
ENST00000473358/Upstream/565; ENST00000471413/Downstream/28371;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/285, chr1-CpG: 44/Downstream/2855
Upstream sequence
TCCTGCCGCAGCTTCCCAA
Junction sequence
TCCTGCCGCAGCTTCCCAAAAAAAGTTSCATGGNGCTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate