Basic Information
VIS ID
TVIS10006540
Fusion event
HBV-LOC102724834 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1739
Integrated sequence
GTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGA| |TTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGA
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh38
Start
90641768 (Hg38)
End
90641768 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC102724834
Nearest miRNA
hsa-let-7i/Upstream/3896619; hsa-mir-1178/Downstream/3920021;
Nearest TSS
ENST00000382841/Upstream/18946; ENST00000549669/Downstream/167508;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/931480, chr12-CpG: 30/Downstream/312259
Nearby gene
ATP2B1-AS1(-929816) ; LINC00615(+276254) ;
Upstream sequence
CCTCTTTTGCCCAAGTGG
Junction sequence
CCTCTTTTGCCCAAGTGGACACCTCCCAGTCCTTAAACAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate