VISDB Viral Integration Site DataBase

VIS ID

TVIS10006549

Fusion event

HBV-EGFR integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1822

Integrated sequence

AAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGT| |ATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATC

Chromosome

chr7

Cytoband

p11.2

Reference genome

Start

End

55119726 (Hg38)

Location type

Intron

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-7-5p ; hsa-mir-145-5p ; hsa-mir-128-3p ; hsa-mir-146a-5p ; hsa-mir-21-5p ; hsa-mir-542-5p ; hsa-mir-128b ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-27a-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-30a-5p ; hsa-let-7a-5p ; hsa-mir-301b-3p ; hsa-mir-574-3p ; hsa-mir-219a-5p ; hsa-mir-302b-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-2861 ; hsa-mir-132-3p ; hsa-mir-875-5p ; hsa-mir-7-1-3p ; hsa-mir-491-5p ; hsa-mir-27b-3p ; hsa-mir-27a-5p ; hsa-mir-125b-5p ; hsa-mir-3622b-5p ; hsa-mir-520b ; hsa-mir-520e ; hsa-mir-133a-5p ; hsa-mir-146b-5p ; hsa-mir-1-5p ; hsa-mir-137 ; hsa-mir-122-5p ; hsa-mir-200a-3p ; hsa-mir-135a-5p

Nearest miRNA

hsa-mir-1183/Upstream/10237926; hsa-mir-10399/Downstream/1836059;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/99314, chr7-CpG: 120/Downstream/134743

Nearest cancer related gene

EGFR(OG, No orient, 0)

Downstream sequence

AACCCACCCTGCCCTGGTT

Junction sequence