OSBP2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006553
Fusion event
HBV-OSBP2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1741
Integrated sequence
CCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATT| |CAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACA
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh38
Start
30891961 (Hg38)
End
30891961 (Hg38)
Location type
Intron
Fragile sites / regions
FRA22B
Target gene
OSBP2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-122-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-1285-5p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4423-3p
Nearest miRNA
hsa-mir-1286/Upstream/160320; hsa-let-7a-3/Downstream/268101;
Nearest TSS
ENST00000624155/Upstream/1012; ENST00000433183/Downstream/1502;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/69055, chr22-CpG: 44/Downstream/13754
Upstream sequence
TGGTCAGGGAGCAGCTTTGC
Junction sequence
TGGTCAGGGAGCAGCTTTGCACTCCTCCCAGTCCTTAANC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate