Basic Information
VIS ID
TVIS10006560
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1828
Integrated sequence
CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh38
Start
1594102 (Hg38)
End
1594102 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1302-11/Upstream/780449; hsa-let-7e/Downstream/222057;
Nearest TSS
ENST00000633603/Upstream/1301; ENST00000586506/Downstream/8027;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1006, chr19-CpG: 71/Downstream/10817
Nearby gene
MBD3(-1341) ; UQCR11(+3052) ;
Downstream sequence
CCGGGTTCAAGTAATTCTCCTG
Junction sequence
CAGCACCATGCAACTTTTTCCCGGGTTCAAGTAATTCTCCTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate