Basic Information
VIS ID
TVIS10006567
Fusion event
HBV-FYB2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
GRCh38
Start
56829818 (Hg38)
End
56829818 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
FYB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-12136/Upstream/1604095; hsa-mir-101-1/Downstream/2903409;
Nearest TSS
ENST00000473358/Upstream/2898; ENST00000361249/Downstream/24988;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/184254, chr1-CpG: 222/Downstream/592473
Nearby gene
FYB2(-10122) ; C8A(+24951) ;
Upstream sequence
CACTTGCACAAAATCAAAGGACAATACAAAGAAATAAAGAGGGAGGAAAAGCAGAAGAGCAAGGAATTAAATTATTCTTACAAAACTTTAAAAAAAAAAA
Downstream sequence
CACTGCACTGTCAAGAGAGACAGGAAGTCAAAATCTGAGCATATTTCAAGAAGTCGATATCTGAGGATATTTTAGGAAACTCATTGTCAGAGGTTAGGAA
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate