Basic Information
VIS ID
TVIS10006571
Fusion event
HBV-C2CD6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1749
Integrated sequence
AGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCG| |ACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTT
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh38
Start
201601445 (Hg38)
End
201601445 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2I
Target gene
C2CD6
Nearest miRNA
hsa-mir-10b/Upstream/12468334; hsa-mir-1244-1/Downstream/5181789;
Nearest TSS
ENST00000437798/Upstream/89618; ENST00000493754/Downstream/17709;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/149160, chr2-CpG: 29/Downstream/17416
Downstream sequence
AGAGAAGAGCAAGATAGAG
Junction sequence
GACTGGGAGGAGTTGGGGGAAGAGAAGAGCAAGATAGAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate