Basic Information
VIS ID
TVIS10006572
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1786
Integrated sequence
GGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCA| |GTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGA
Host Sequence
Chromosome
chr1
Cytoband
q24.2
Reference genome
GRCh38
Start
167529560 (Hg38)
End
167529560 (Hg38)
Location type
Intronic
Target gene
AKR1D1P1 ; LOC107985224
Nearest miRNA
hsa-mir-101-1/Upstream/1374762; hsa-mir-1182/Downstream/469100;
Nearest TSS
ENST00000473358/Upstream/10950; ENST00000461790/Downstream/16620;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/73581, chr1-CpG: 82/Downstream/23672
Nearby gene
CD247(-10950) ; CREG1(+11453) ;
Downstream sequence
AGTTGTATTAGCTTTCTATTGC
Junction sequence
TTTATGTATTAGGAGGCTGTTGAGTTGTATTAGCTTTCTATTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate