Fusion event
HBV-ATP2C1 integration
Detection method
invPCR +Sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/1666575; hsa-mir-1224/Downstream/1047037;
Upstream sequence
CCAAGTGAGTGATATGACCCACTGGACCACTAACTGGACCTTCTTGCGTCTTTAAGAATGTGTCAGATATGTGGAGTGCCCTACTTCAGAAGGATTCCTG
Downstream sequence
CAAATAGTATCACTATGTATGGAAGACCTTAGTACCTTGTTCTCTTTGATCACTAGAAAGCCCATGTTTTCAAAAAACACCACAAAATTGTGATTTTAAC
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.