Basic Information
VIS ID
TVIS10006578
Fusion event
HBV-NREP integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1924
Integrated sequence
ATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGG| |CAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCCCATGACCAAGCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCACAGACCTGGCCGT
Host Sequence
Chromosome
chr5
Cytoband
q22.1
Reference genome
GRCh38
Start
111924181 (Hg38)
End
111924181 (Hg38)
Location type
Intron
Target gene
NREP
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-29b-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3613-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-mir-10397/Upstream/1410266; hsa-mir-103a-1/Downstream/4331562;
Nearest TSS
ENST00000502646/Upstream/11673; ENST00000508389/Downstream/15872;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/165964, chr5-CpG: 51/Downstream/236529
Upstream sequence
GCTGGGCCTTGGATTTTGAAA
Junction sequence
GCTGGGCCTTGGATTTTGAAACTTTATAAAGATCAATGTCC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate