ZAP70 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006582
Fusion event
HBV-ZAP70 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1761
Integrated sequence
CCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAA| |CAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGAT
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh38
Start
97732649 (Hg38)
End
97732649 (Hg38)
Location type
Intron
Fragile sites / regions
FRA2S ; FRA2A
Target gene
ZAP70
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-34b-3p ; hsa-mir-34c-5p ; hsa-mir-631
Nearest miRNA
hsa-mir-1285-2/Upstream/934296; hsa-mir-10b/Downstream/3576801;
Nearest TSS
ENST00000437798/Upstream/8188; ENST00000498836/Downstream/53;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8153, chr2-CpG: 22/Downstream/1872
Upstream sequence
CATCTGTTGGCTCTTGGAGA
Junction sequence
CATCTGTTGGCTCTTGGAGAAATCTAATCTCCTCCCCCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate