Basic Information
VIS ID
TVIS10006584
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1767
Integrated sequence
GTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGG| |ACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTT
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh38
Start
70563526 (Hg38)
End
70563526 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/13173314; hsa-mir-10524/Downstream/813434;
Nearest TSS
ENST00000381078/Upstream/6828; ENST00000468640/Downstream/3391;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/149409, chr6-CpG: 47/Downstream/3312
Nearby gene
FAM135A(-2352) ; SDHAF4(+3395) ;
Upstream sequence
CTAGGTTGCTGCAGTTTCAT
Junction sequence
CTAGGTTGCTGCAGTTTCATAACCTTTAATCTNATCTCCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate