Basic Information
VIS ID
TVIS10006587
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1828
Integrated sequence
CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh38
Start
45585702 (Hg38)
End
45585702 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/148998; hsa-let-7e/Downstream/53292;
Nearest TSS
ENST00000633603/Upstream/860; ENST00000591322/Downstream/14051;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/615, chr19-CpG: 64/Downstream/5374
Nearby gene
OPA3(-838) ; GPR4(+4062) ;
Upstream sequence
TCAGAAATAAATTTAAGGAC
Junction sequence
TCAGAAATAAATTTAAGGACGAAAAAGTTGCATGGTGCTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate