VISDB Viral Integration Site DataBase

VIS ID

TVIS10006591

Fusion event

HBV-THRB integration

Validated

Yes

Detection method

invPCR +Sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Perfect

Reported year

2016

PubMed ID

Virus name

HBV

Reference genome

Start

1949

Integrated sequence

ATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGC| |ATGCGCTGATGGCCCATGACCAAGCCCCAGCCAGTGGGGGTTGCGTCAGCAAACACTTGGCACAGACCTGGCCGTTGCCGGGCAACGGGGTAAAGGTTCA

Chromosome

chr3

Cytoband

p24.2

Reference genome

Start

End

24420709 (Hg38)

Location type

Intron

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-27a-3p ; hsa-mir-204-5p ; hsa-mir-155-5p ; hsa-mir-425-5p ; hsa-mir-452-5p ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-3161 ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-3926 ; hsa-mir-4778-5p ; hsa-mir-4753-5p ; hsa-mir-6794-3p ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-15b-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-101-3p ; hsa-mir-200a-3p ; hsa-mir-1238-5p ; hsa-mir-129-5p ; hsa-mir-3659 ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-574-5p ; hsa-mir-6790-5p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-1537-5p ; hsa-mir-320a ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-3607-3p ; hsa-mir-4429 ; hsa-mir-4633-3p ; hsa-mir-4793-5p ; hsa-mir-5002-5p ; hsa-mir-5196-3p ; hsa-mir-6500-5p ; hsa-mir-6870-3p ; hsa-mir-6874-5p ; hsa-mir-9-3p

Nearest miRNA

hsa-mir-12127/Upstream/4283068; hsa-let-7g/Downstream/1244164;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/474179, chr3-CpG: 135/Downstream/73644

Nearest cancer related gene

THRB(TSG, No orient, 0)

Downstream sequence

TGGCAAGGTTGCAGAGTAAAAGG

Junction sequence