Basic Information
VIS ID
TVIS10006599
Fusion event
HBV-IGH integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1810
Integrated sequence
AGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCA| |TGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCC
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh38
Start
106076891 (Hg38)
End
106076891 (Hg38)
Location type
Intronic
Target gene
IGH
Nearest miRNA
hsa-mir-1185-1/Upstream/217338; hsa-mir-5195/Downstream/773994;
Nearest TSS
ENST00000550708/Upstream/14208; ENST00000605005/Downstream/11682;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/208830, chr14-CpG: 17/Downstream/136945
Nearby gene
ADAM6(-104622) ; LINC00226(+210782) ;
Downstream sequence
ATAAAATGTATATGCA
Junction sequence
TAAATTGGTCTGCNCACCAATAAAATGTATATGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate