Basic Information
VIS ID
TVIS10006600
Fusion event
HBV-LOC105375694 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1786
Integrated sequence
GGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCA| |GTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGA
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh38
Start
104886603 (Hg38)
End
104886603 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
LOC105375694
Nearest miRNA
hsa-mir-12123/Upstream/402138; hsa-mir-10400/Downstream/7756890;
Nearest TSS
ENST00000518652/Upstream/182884; ENST00000522160/Downstream/302003;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/297127, chr8-CpG: 136/Downstream/431674
Nearby gene
LRP12(-297579) ; ZFPM2(+432315) ;
Upstream sequence
AAATCCTCTCTTTAGC
Junction sequence
AAATCCTCTCTTTAGCACAGCCTCCTAATACATAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate