Basic Information
VIS ID
TVIS10006601
Fusion event
HBV-MEF2C-AS1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1790
Integrated sequence
AAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTG| |GCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAA
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh38
Start
89178690 (Hg38)
End
89178690 (Hg38)
Location type
Intronic
Target gene
MEF2C-AS1
Nearest miRNA
hsa-mir-10397/Upstream/511751; hsa-mir-103a-1/Downstream/837931;
Nearest TSS
ENST00000502646/Upstream/212815; ENST00000508742/Downstream/240117;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/288918, chr5-CpG: 17/Downstream/1230836
Nearby gene
MEF2C-AS1(-146314) ; LINC01339(+979648) ;
Downstream sequence
GGGCAGAGAAATGTGATATG
Junction sequence
TATTAGGAGGCTGTAGGCGGGCAGAGAAATGTGATATG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate