Basic Information
VIS ID
TVIS10006602
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
3009
Integrated sequence
AATTGAGAGAAGTCCACCACGAGTCTAGACTCTGCGGTATTGTGAGGATTCTTGTCAACAAGAAAAACCCCGCCTGTAACACGAGAAGGGGTCCTAGGAA| |TCCTGATGTGATGTTCTCCATGTTCAGCGCAGGGTCCCCAATCCTCGAGAAGATTGACGATAAGGGAGAGGCAGTAGTCAGAACAGGGTTTACTGTTCCT
Host Sequence
Chromosome
chr18
Cytoband
q22.1
Reference genome
GRCh38
Start
64044086 (Hg38)
End
64044086 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/5592928; hsa-mir-5011/Downstream/3037498;
Nearest TSS
ENST00000575820/Upstream/58910; ENST00000417298/Downstream/54524;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/41065, chr18-CpG: 88/Downstream/1706514
Nearby gene
SERPINB8(-54712) ; LINC00305(+35922) ;
Downstream sequence
GGTTTGTTCTTTCACTGT
Junction sequence
CCGCCTCCTGCCTCCACCAAGGTTTGTTCTTTCACTGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate