Basic Information
VIS ID
TVIS10006611
Fusion event
HBV-chr10 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1805
Integrated sequence
TCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGC| |AGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGA
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh38
Start
42917286 (Hg38)
End
42917286 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10G
Nearest miRNA
hsa-mir-1265/Upstream/7276034; hsa-mir-107/Downstream/80277;
Nearest TSS
ENST00000439456/Upstream/45765; ENST00000638465/Downstream/64221;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/18317, chr10-CpG: 95/Downstream/15433
Nearby gene
BMS1(-82349) ; LINC01264(+61730) ;
Downstream sequence
AAAAAATTGAAAACAGC
Junction sequence
TAGGCATAAATTGGTCTGCGAAAAAATTGAAAACAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate