Basic Information
VIS ID
TVIS10006639
Fusion event
HBV-chr1 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1828
Integrated sequence
CGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTT| |GCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGA
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh38
Start
235916277 (Hg38)
End
235916277 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LINC02768 ; LOC105373215
Nearest miRNA
hsa-mir-101-1/Upstream/63217; hsa-mir-3123/Downstream/1554842;
Nearest TSS
ENST00000473358/Upstream/32637; ENST00000366591/Downstream/27528;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/48980, chr1-CpG: 37/Downstream/77296
Nearby gene
LYST(-32569) ; NID1(+59554) ;
Upstream sequence
TCAACCTCTGGAATTTTGA
Junction sequence
TCAACCTCTGGAATTTTGAGAAAAAGTTGCATGATGATG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
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