Basic Information
VIS ID
TVIS10006643
Fusion event
HBV-chr3 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1826
Integrated sequence
GTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATAT| |TTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCA
Host Sequence
Chromosome
chr3
Cytoband
q25.31
Reference genome
GRCh38
Start
156586391 (Hg38)
End
156586391 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA3D
Nearest miRNA
hsa-let-7g/Upstream/5020396; hsa-mir-1224/Downstream/2696255;
Nearest TSS
ENST00000440867/Upstream/31207; ENST00000473702/Downstream/86479;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/31081, chr3-CpG: 191/Downstream/87631
Nearby gene
SSR3(-31191) ; TIPARP-AS1(+86779) ;
Downstream sequence
GTTTAGGCTTGGCCTCATCACA
Junction sequence
ACCATCATCATGCCACTTTTGTTTAGGCTTGGCCTCATCACA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate