VAV2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10006645
Fusion event
HBV-VAV2 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr9
Cytoband
q34.2
Reference genome
GRCh38
Start
133881250 (Hg38)
End
133881250 (Hg38)
Location type
Intron
Target gene
VAV2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-320a ; hsa-let-7a-5p ; hsa-mir-148a-3p ; hsa-mir-218-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-6090 ; hsa-mir-6081 ; hsa-mir-6827-5p ; hsa-mir-6124 ; hsa-mir-873-5p ; hsa-mir-3192-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6165 ; hsa-mir-4524b-3p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-1273d ; hsa-mir-4493 ; hsa-mir-4753-5p
Nearest miRNA
hsa-let-7a-1/Upstream/829191; hsa-mir-126/Downstream/498161;
Nearest TSS
ENST00000422679/Upstream/141295; ENST00000432807/Downstream/58051;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/17772, chr9-CpG: 30/Downstream/12089
Nearest cancer related gene
VAV2(OG, No orient, 0)
Upstream sequence
CACAGAGAGATGCGGCC
Junction sequence
CACAGAGAGATGCGGCCGGACCTTTAACCTAATCTCCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate