Basic Information
VIS ID
TVIS10006661
Fusion event
HBV-LOC105370805 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1863
Integrated sequence
AAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAA| |TGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAGTTCCGCAGTATGGATCGGCAGAGGAGCCGAAAAGGTTCCACGCATGCGCTGATGGCC
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh38
Start
48030022 (Hg38)
End
48030022 (Hg38)
Location type
Intronic
Target gene
LOC105370805
Nearest miRNA
hsa-mir-10393/Upstream/2596893; hsa-mir-11181/Downstream/1139048;
Nearest TSS
ENST00000557528/Upstream/85978; ENST00000482911/Downstream/90950;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/311175, chr15-CpG: 53/Downstream/147788
Nearby gene
SEMA6D(-255799) ; SLC24A5(+90949) ;
Upstream sequence
TTTCAACTCTTCCTGCCTGC
Junction sequence
TTTCAACTCTTCCTGCCTGCCAAAGTGGGACATGTACAAGAGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate