Basic Information
VIS ID
TVIS10006664
Fusion event
HBV-chr7 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1771
Integrated sequence
GTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGT| |CCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCT
Host Sequence
Chromosome
chr7
Cytoband
p12.3
Reference genome
GRCh38
Start
46572890 (Hg38)
End
46572890 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1183/Upstream/1691090; hsa-mir-10399/Downstream/10382895;
Nearest TSS
ENST00000635602/Upstream/91312; ENST00000429010/Downstream/124232;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/651142, chr7-CpG: 86/Downstream/479756
Nearby gene
IGFBP3(-651618) ; TNS3(+702263) ;
Nearest cancer related gene
IGFBP3(TSG, -651618) ;
Downstream sequence
ACCCTGTGAATTATGGTGC
Junction sequence
AGATTAGGTTAAAGGTCTTTACCCTGTGAATTATGGTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate