Basic Information
VIS ID
TVIS10006665
Fusion event
HBV-chr3 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1806
Integrated sequence
CCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCA| |GCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCTCCAGACCTGCTGCGAGCAAAACAAGCGGCTAGGAG
Host Sequence
Chromosome
chr3
Cytoband
p22.1
Reference genome
GRCh38
Start
41060244 (Hg38)
End
41060244 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/1921978; hsa-let-7g/Downstream/3053968;
Nearest TSS
ENST00000440867/Upstream/88666; ENST00000426215/Downstream/108303;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/444340, chr3-CpG: 153/Downstream/138427
Nearby gene
ZNF621(-520449) ; CTNNB1(+139208) ;
Nearest cancer related gene
CTNNB1(OG, +139208) ;
Upstream sequence
TTGAAGATCAGCTGACTGTAG
Junction sequence
TTGAAGATCAGCTGACTGTAGGCGCAGACCAATTTATNCCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate