Basic Information
VIS ID
TVIS10006667
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr18
Cytoband
q12.2
Reference genome
GRCh38
Start
35238602 (Hg38)
End
35238602 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA18A
Nearest miRNA
hsa-mir-1-2/Upstream/4939642; hsa-mir-122/Downstream/353135;
Nearest TSS
ENST00000575820/Upstream/93660; ENST00000601719/Downstream/2428;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/196877, chr18-CpG: 42/Downstream/2219
Nearby gene
MAPRE2(-95134) ; ZNF397(+2427) ;
Upstream sequence
AAGGGAATCAGATTACCTATCAAAgcagatattactgttgcaaattcaacattcatctatttatctcccttttctgcctttttaacacagccctaatttc
Downstream sequence
atgcattctccccagagtgtctgtgtcctttaggagaggctggccttctccttagccctgggatataaatttcaattgtcctaatcccaccatggaggcc
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate