Basic Information
VIS ID
TVIS10006671
Fusion event
HBV-chr4 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
GRCh38
Start
120612857 (Hg38)
End
120612857 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5956003; hsa-mir-1305/Downstream/4894402;
Nearest TSS
ENST00000502981/Upstream/545346; ENST00000506100/Downstream/26233;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/545856, chr4-CpG: 127/Downstream/309136
Nearby gene
MAD2L1(-546123) ; PRDM5(+79055) ;
Nearest cancer related gene
PRDM5(TSG, +79055) ;
Upstream sequence
ATTTTTCTCTGGCATACATAGGCTTCCAAAAGGATTATTGCTAATTTAGCCTGAAATTGTATTTTGATAATTCAATATAGGGCAATTATGACTTAAAGGG
Downstream sequence
GCTAGCTCTGTAGAACAATACATTTGGTTGATTAGTAAAATCGGGTGACAAGACATCCAGTGAACACATTCTGGGAGGAAGCACAGTCTTTGTTATTATA
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate