Basic Information
VIS ID
TVIS10006674
Fusion event
HBV-chr6 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1704
Integrated sequence
ACACGGTCCGGCAGATGAGAAGGCACAGACGGGGAGTCCGCGTAAAGAGAGGTGCGCCCCGTGGTCGGTCGGAACGGCAGACGGAGAAGGGGACGAGAGA| |GTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACAGCCTAG
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh38
Start
105969056 (Hg38)
End
105969056 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA6F
Nearest miRNA
hsa-mir-10398/Upstream/6844360; hsa-mir-1202/Downstream/815069;
Nearest TSS
ENST00000381078/Upstream/76015; ENST00000424894/Downstream/117264;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/565674, chr6-CpG: 57/Downstream/12180
Nearby gene
PREP(-565932) ; PRDM1(+117263) ;
Nearest cancer related gene
PRDM1(TSG, +117263) ;
Upstream sequence
TTGTTAATTGCACCACTTC
Junction sequence
TTGTTAATTGCACCACTTCTGCCTCAAGGTCGGTCGTTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
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