Basic Information
VIS ID
TVIS10006681
Fusion event
HBV-chr8 integration
Validated
Yes
Detection method
invPCR +Sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27453547
Virus Sequence
Virus name
HBV
Reference genome
V01460.1
Start
1771
Integrated sequence
GTCGGAACGGCAGACGGAGAAGGGGACGAGAGAGTCCCAAGCGACCCCGAGAAGGGTCGTCCGCAGGATTCAGCGCCGACGGGACGTAAACAAAGGACGT| |CCCGCGCAGGATCCAGTTGGCAGCACAGCCTAGCAGCCATGGAAACGATGTATATTTGCGGGATAGGACAACAGAGTTATCAGTCCCGATAATGTTTGCT
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh38
Start
81218770 (Hg38)
End
81218770 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/977297; hsa-mir-10400/Downstream/9986715;
Nearest TSS
ENST00000518652/Upstream/64440; ENST00000486269/Downstream/58800;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/106629, chr8-CpG: 111/Downstream/61373
Nearby gene
PAG1(-106702) ; FABP5(+61712) ;
Upstream sequence
ACACCTGGCTAACTTTTTAT
Junction sequence
ACACCTGGCTAACTTTTTATAAAGNCCTTTAACCTAACCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Mason, W. S., et al. HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant. Gastroenterology,2016, 151(5): 986-998 e984.
Curate